Challenges Associated with the Quantification of Tear Fluids

Eye is second most complex organ of the body after brain. Drug delivery to the eye is the challenging task for the pharmaceutical scientists. Topical administration to the eye is the most convenient and commonly used for the pharmacological therapy. Effectiveness of the drugs can only be determined by the pharmacokinetics and pharmacodynamics correlation. Ocular pharmacokinetics is the essential part in the drug development for the eye. Pharmacokinetics characteristics of the drug deliver to the eye is very complex. Moreover, assessment of the pharmacokinetic properties is very difficult. After topical administration of the drugs in to eye, collection of ocular tissue and aqueous humor is the routine practice in the animals. It’s very difficult to conduct the study in humans. Thus, quantification of the tears is the most useful tools to study ocular pharmacokinetics [1-4].